Botox or Xeomin? Find the Best Wrinkle Treatment for You

What Is Botox?

Botox is an FDA-approved neurotoxin injection derived from Clostridium botulinum. It works by temporarily relaxing the muscles that cause wrinkles, making your skin look smoother. Botox is primarily used for the upper face, targeting areas such as forehead lines, crow’s feet around the eyes, and the frown lines between your eyebrows.

The treatment is quick, non-invasive, and requires little to no downtime. Regular use of Botox can actually help prevent new wrinkles from forming, as it trains your facial muscles to relax.

Apart from wrinkle reduction, Botox is also a treatment for: 

• Chronic migraines
• Cervical dystonia (muscle spasms in the shoulders and neck)
• Overactive bladder
• Hyperhidrosis (excessive sweating)
• Strabismus (crossed eyes)
• Blepharospasm (eyelid spasms)
• Spasticity (muscle stiffness)
• Sialorrhea (excessive drooling)
• Vocal cord dysfunction
• Temporomandibular joint disorder (TMJ)

What Is Xeomin?

Xeomin is another FDA-approved injectable used to treat fine lines and wrinkles, particularly frown lines between the eyebrows (also known as glabellar lines). Like Botox, Xeomin is derived from botulinum toxin, but there’s a key difference: Xeomin is a "naked" form of the toxin, meaning it doesn’t contain the additional proteins that are in Botox.

This purified composition makes Xeomin an excellent option for people who may have developed a resistance to Botox over time. Because there are no accessory proteins, there’s less risk of your body developing antibodies that can render the treatment less effective.

Like Botox, Xeomin can be effective in treating certain medical issues, such as:

• Cervical dystonia 
• Blepharospasm 
• Sialorrhea 
• Muscle stiffness in the upper limbs

Key Differences Between Botox and Xeomin

Choosing between Botox and Xeomin comes down to your individual skin concerns, medical history, and aesthetic goals. Both injectables are safe and effective when administered by a trained professional. 

We’ve broken down the distinctions between the two wrinkle treatments to help you figure out which one suits you best.

Purity

One of the main distinctions between Botox and Xeomin is the formulation. While Botox contains additional proteins along with the active ingredient (botulinum toxin type A), Xeomin is free of these proteins. This “naked” formula means Xeomin has a reduced risk of causing resistance in patients who receive frequent injections. For people who are concerned about becoming immune to the effects of Botox, Xeomin may be a better long-term solution.

Onset of Results

Botox typically starts working within 3 to 5 days after injection, making it ideal for individuals looking for quicker wrinkle-reducing effects. Xeomin, however, may take a little longer to kick in, with results generally appearing within 5 to 7 days. It’s a subtle difference, but it might be worth considering if you want to schedule treatments for an event or need quicker results.

Longevity of Results

Botox and Xeomin work through the same mechanism—blocking nerve signals to temporarily relax the targeted muscles, preventing them from contracting and causing wrinkles. On average, the effects of both treatments last between 3 to 4 months, depending on factors such as metabolism, lifestyle, and the area being treated. 

Frequently Asked Questions

1. How should I prepare for my treatment?

Before your treatment, avoid consuming alcohol, aspirin, ibuprofen, or any blood-thinning supplements for at least 24 hours. Also, avoid vigorous exercise or heat exposure. Discuss any medicines, supplements, or health conditions with your provider to ensure an effective and safe treatment.

2. What should I expect during treatment?

Both treatments are straightforward. Most sessions last about 10 to 15 minutes, and patients often return to their regular activities immediately after. A small needle is used to inject the solution into the targeted muscles. Most patients describe the feeling as a slight pinch or sting, and discomfort is generally minimal. The number of injections you’ll need depends on the severity of your wrinkles and the areas you’re treating.

3. What steps should I take after treatment?

After your procedure, don’t touch or rub the treated areas for at least four hours, as this could cause the product to migrate to unintended areas. It can potentially lead to complications such as drooping eyelids. It's also recommended to stay upright (don’t lie down) for about four hours post-treatment.

Avoid strenuous physical activities, intense heat (like saunas or hot baths), and alcohol consumption for 24–48 hours after treatment to prevent swelling and bruising. Follow your provider’s aftercare instructions closely.

4. What are the typical side effects of Botox or Xeomin?

Most side effects are temporary and mild, such as swelling, redness, or slight bruising at the injection site. Some people may experience headaches or drooping eyelids, though these are less common. If you notice any severe reactions or persistent issues, contact your healthcare provider.

5. Can these two wrinkle treatments be used together in a single treatment session?

Combining different botulinum toxin A products, such as Botox and Xeomin, in the same treatment is not advisable. If you're interested in trying both, start with one and wait a period of time before trying the other. The effects of using them together have not been studied. Although both are neurotoxins, their chemical compositions vary slightly.

6. Is it safe to repeat these cosmetic injectables over time?

Yes, you can safely have Botox or Xeomin injections repeatedly. Most patients schedule treatments every 3 to 4 months, depending on how long the effects last. 

Over time, some people may require less frequent injections to maintain the desired effect. However, others may need consistent treatments every few months. It’s important to attend follow-up appointments to evaluate how well the treatment is working and to make any necessary adjustments to the dosage or frequency of injections.

7. Which is better, Botox or Xeomin?

Both Botox and Xeomin deliver similar results, and one isn’t necessarily better than the other. The choice often depends on individual factors like your body’s response to the treatment or if you've developed resistance to one brand. Discuss your preferences and goals with your provider to decide which is best for you.

Get Safe and Effective Wrinkle Treatments!

Ready to smooth away those wrinkles? Whether you're considering Xeomin or Botox, consulting with a professional is the best way to make the right choice for your skin. At Clínica Médica General (CMG), we’re here to help you find the ideal treatment that delivers safe, effective results.

And don't miss out on our special September promo: Receive $75 off your first eligible SmartTox (Xeomin) treatment! Our FDA-approved smoothing injections are perfect for targeting moderate to severe upper facial lines. 

Contact our skincare expert today to schedule a consultation and discover the best cosmetic treatment.